Yes, some patients taking Mounjaro may experience a noticeable loss of facial volume. This is not a direct result of the medicine’s action, but stems from a reduction in body fat throughout the body, including the face. This most commonly affects the cheeks, temples and the area around the jaw. The rate and extent of these changes vary from person to person and depend, amongst other things, on the amount of weight lost, age and skin elasticity. In people who lose weight gradually and have good skin condition, the changes may be less noticeable. In the case of rapid weight loss, the loss of facial volume may be more noticeable.