The needle mesotherapy treatment does not require any special preparations. However, you must remember not to take antibiotics or anticoagulants or anti-inflammatory drugs a few days beforehand. It is also a good idea to refrain from using scrubs or rough sponges so as not to irritate your face. The day before and on the day of your treatment, do not consume alcohol. If you are susceptible to herpes consider taking a prophylactic antiviral medication such as acyclovir before your treatment.