When first starting Mounjaro for the treatment of obesity, patients may experience various changes in their sense of appetite and fullness. One of the most commonly reported effects is a reduction in feelings of hunger and a faster onset of fullness after meals. Some people also find they have greater control over the amount of food they eat, which makes it easier to achieve a calorie deficit. The first few weeks of treatment are a period of adaptation for the body, so reactions may vary between patients. During this time, the body adapts to new mechanisms of metabolic regulation, which is a natural stage of treatment.